Diabetic retinopathy is a complication of uncontrolled diabetes that leads to impaired vision and blindness among people with diabetes. High blood glucose levels result in the abnormal development of tiny blood vessels in the eye. Research has shown that tight glycaemic control reduces the development and progression of diabetic retinopathy. However, the way in which high blood glucose levels affect blood vessel development in the eye is not completely understood.
Michael D. Dennis, PhD, is working on the assumption that high blood glucose contributes to retinopathy by altering the genes that get made into proteins in a manner that results in retinopathy.